DISAPPEARANCE OF ISLET CELL ANTIBODIES (ICA) MAY BE ASSOCIATED WITH EITHER DETERIORATION OR AMELIORATION OF ISLET CELL FUNCTION

Islet cell antibodies in diabetes mellitus.

Islet-cell antibodies (I.C.A.) were found in 38% (319/829) of insulin-dependent diabetic patients, in 5% (6/112) of insulin-independent diabetics, and in 1.7% (3/177) of non-diabetic subjects. In the insulin-dependent group I.C.A. were found in 85% of patients immediately after the onset of symptoms and they became less common as the duration of disease increased I.C.A. were equally common in b...

Beta Cell Function After Islet Transplantation

Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in stiff man syndrome.

Cytoplasmic islet cell antibodies are well-established predictive markers of IDDM. Although target molecules of ICA have been suggested to be gangliosides, human monoclonal ICA of the immunoglobulin G class (MICA 1-6) produced from a patient with newly diagnosed IDDM recognized glutamate decarboxylase as a target antigen. Here we analyzed the possible heterogeneity of target antigens of ICA by ...

Imaging Islet Cell Tumours

Islet cell tumours are rare lesions. The majority (85%) are functioning hormone-producing tumours, insulinomas and gastrinomas being the most common. Approximately 15% of islet cell tumours are nonfunctioning. These are usually larger lesions, often presenting at an advanced stage as a pancreatic mass or with metastatic disease. This review will focus on the role of endoscopic ultrasound in the...

The islet ghrelin cell.

The islets of Langerhans are key regulators of glucose homeostasis and have been known as a structure for almost one and a half centuries. During the twentieth century several different cell types were described in the islets of different species and at different developmental stages. Six cell types with identified hormonal product have been described so far by the use of histochemical staining...